Heat oven to 375°F. In large bowl, mix ground turkey, 1/2 cup of the ketchup, the bread crumbs, 2 teaspoons of the Worcestershire sauce, 1/4 teaspoon pepper, the garlic and egg. Evenly spread mixture in ungreased 8×4- or 9×5-inch loaf pan.
In small bowl, mix remaining 1/2 cup ketchup, remaining 1 teaspoon Worcestershire sauce and the mustard; spread evenly over top of meatloaf.
Bake uncovered 55 to 60 minutes or until meat thermometer inserted in center of loaf reads at least 165°F. Let stand 5 minutes.